Novel composite nanoparticles based on glycidyl methacrylate‐derivatized dextrans and gelatin as new bone morphogenetic protein carrier

Enzymatic crosslinking and degradation of gelatin as a switch for bone morphogenetic protein-2 activity.

Current therapies for tissue regeneration rely on the presence or direct delivery of growth factors to sites of repair. Bone morphogenetic protein-2 (BMP-2), combined with a carrier (usually collagen), is clinically proven to induce new bone formation during spinal fusion and nonunion repair. However, due to BMP-2's short half-life and its diffusive properties, orders of magnitude above physiol...

A Novel Bone Scaffold Material Based on Collagen/hydroxyapatite/gelatin Composite

XICHAN HE, TINGTING YAN, KEYONG TANG, MADALINA GEORGIANA ALBU, MIHAELA VIOLETA GHICA 1 College of Materials Science and Engineering, Zhengzhou University, Henan 450001, China, [email protected] 2 INCDTP Division Leather and Footwear Research Institute, Collagen Department, 93 Ion Minulescu Str., 031215, Bucharest, Romania 3 “Carol Davila” University of Medicine and Pharmacy, Faculty of Phar...

A Novel Porous Gelatin Composite Containing Naringin for Bone Repair

As Gu-Sui-Bu (GSB) is a commonly used Chinese medical herb for therapeutic treatment of bone-related diseases, naringin is its main active component. This study elucidates how various concentrations of naringin solution affect the activities of bone cells, based on colorimetric, alkaline phosphatase activity, nodule formation, and tartrate-resistant acid phosphatase activity assays to determine...

Novel Composite Scaffolds from Gelatin, Chitooligosaccharide, and Demineralized Bone for Bone Tissue Engineering

Premixed calcium phosphate cement as a carrier of bone morphogenetic protein

Aims Bone defects caused by bone loss due to trauma or tumours are common, with grafting of transplanted tissue currently as the gold standard for bone replacement. However, there are many issues inherent with autograft, including donor site morbidity, supply of tissue and infection [1]. In order to overcome these drawbacks, a diverse array of synthetic biomaterials is under development [2]. Ca...